The overarching theme of my research career is determining how genetic variation leads to skin cancers – melanoma and the keratinocyte cancers basal cell carcinoma and squamous cell carcinoma. I am also interested in the genetics of related skin traits such as skin aging. Skin cancers have a huge impact in terms of health care costs and loss of quality of life, and it is critical we better understand why people develop these conditions. I do this through large scale GWAS meta-analyses of national and international cohorts, and by applying/exploring the result of those studies. One such way I apply the results of these GWAS is through polygenic risk scores.